Talk:Lipid-based nanoparticle/Archive 1
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| Archive 1 |
Need to fully identify the inline references and try to find free access sources
Text (probably copied from Seyfoddin (2010)) refers to (Mehnert et al., 2001 and Small, 1986), (Manzunath et al., 2005).
but hasnt included the full references. A great shame as the only reference now is to a pay-to-view article.
(Mehnert 2001 is probably Solid lipid nanoparticles: Production, characterization and applications. sadly also pay-to-view.)
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Muller et al. 2000 (17 pages, 126 refs) looks good and is free. It discusses the main production methods eg. high pressure homogenization, and others. - Rod57 (talk) 21:03, 3 December 2012 (UTC)
- This change in Sept 2011 lost 2 decent sources (of 4) from the intro. Those refs here.[1][2] - Have put back in intro for now. Ref 1 shows 26 refs up to 2006. - Rod57 (talk) 03:05, 5 December 2012 (UTC)
- ^ Saupe, Anne; Rades, Thomas (2006). "Nanocarrier Technologies": 41. doi:10.1007/978-1-4020-5041-1_3. ISBN 978-1-4020-5040-4.
{{cite journal}}:|chapter=ignored (help); Cite journal requires|journal=(help) - ^ Jenning, V; Thünemann, AF; Gohla, SH (2000). "Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids". International journal of pharmaceutics. 199 (2): 167–77. PMID 10802410.
Needs structural revision
Why was the characteristics and production section introduced after the mechanism and application sections? I think it would read a little smoother to explain what the particles actually are before going into the details on how they work and could be used. A little more context on how they are used for drug delivery would also be very helpful. Madisonmonahan (talk) 03:26, 16 January 2018 (UTC)
The diagrams in the article are incorrect
The articles published by Cullis et al. indicate that the lipid nanoparticles currently in common use have an outer layer of PEGylated lipids wrapped around inverse micelles on the inside (heads in, tails out) which encapsulate mRNA payloads. The diagrams in the article do not correctly depict this. Precision NanoSystems depicts LNPs correctly on the front page of their Web site. --Coolcaesar (talk) 18:20, 12 March 2021 (UTC)
The focus of the page is incorrect
Following a litterature review, it appears to me that Solid Lipid Nanoparticle (or SLN) actually are a sub-category of the Lipid-based nanoparticle category (or lipid-based nanoparticle carrier), which contains the Lipid Nanoparticles (LNP) as another sub category.
Therefore here starting the article on "Solid lipid nanoparticle" by defining "lipid nanoparticles (LNPs)" is both off topic (2 different things) + the definition of LNP is wrong.
Indeed the definition given "nanoparticles composed of lipids", corresponds to the "lipid based nanoparticle" definition, neither SLN or LNP, while "Lipid nanoparticles" corresponds to the subcategory of "lipid based nanoparticles encapsulating various types of nucleic acids (mRNA, siRNA...) ". It might be interesting to open another specific page on the "lipid nanoparticle (LNP)" itself. Robin11111111 (talk) 13:31, 19 January 2023 (UTC)