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She was awarded the Society for Neuroscience’s Research Award for Innovation in Neuroscience and the Career Development Award in 2008, and she received the Humboldt Foundation’s Bessel Research Award as well in 2009<ref>{{Cite web |title=Prof. Dr. Alison L. Barth |url=https://www.humboldt-foundation.de/en/connect/explore-the-humboldt-network/singleview/1135186/prof-dr-alison-l-barth |access-date=2024-04-29 |website=www.humboldt-foundation.de |language=en}}</ref><ref>{{Cite web |last=University |first=Carnegie Mellon |title=Early Career Awards - Mellon College of Science - Carnegie Mellon University |url=http://www.cmu.edu/mcs/about/awards/faculty/early-career.html |access-date=2024-04-29 |website=www.cmu.edu |language=en}}</ref><ref>{{Cite web |title=Speakers |url=https://nm2.epfl.ch/nm2-2019/speakers/ |access-date=2024-04-29 |website=EPFL |language=en-GB}}</ref><ref>{{Cite web |title=Connect with Faculty Expert Alison Barth - News - Carnegie Mellon University |url=https://www.cmu.edu/news/experts/alison.barth |access-date=2024-04-29 |website=www.cmu.edu |language=en}}</ref><ref>{{Cite web |date=2024-04-20 |title=Carnegie Mellon University Celebrates Five Faculty Elected as 2023 AAAS Fellows |url=https://indiaeducationdiary.in/carnegie-mellon-university-celebrates-five-faculty-elected-as-2023-aaas-fellows/ |access-date=2024-04-29 |website=India Education {{!}} Latest Education News {{!}} Global Educational News {{!}} Recent Educational News |language=en-US}}</ref><ref name=":5">{{Cite web |last=Opdyke |first=Heidi |date=April 18, 2024 |title=Barth, Tetali Elected 2023 AAAS Fellows |url=http://www.cmu.edu/mcs/news-events/2024/0418_aaas-fellows-announcement.html |access-date=2024-04-29 |website=www.cmu.edu |language=en}}</ref>. Barth was elected as one of the 2023 fellows of the [[American Association for the Advancement of Science]]<ref name=":5" />.
She was awarded the Society for Neuroscience’s Research Award for Innovation in Neuroscience and the Career Development Award in 2008, and she received the Humboldt Foundation’s Bessel Research Award as well in 2009<ref>{{Cite web |title=Prof. Dr. Alison L. Barth |url=https://www.humboldt-foundation.de/en/connect/explore-the-humboldt-network/singleview/1135186/prof-dr-alison-l-barth |access-date=2024-04-29 |website=www.humboldt-foundation.de |language=en}}</ref><ref>{{Cite web |last=University |first=Carnegie Mellon |title=Early Career Awards - Mellon College of Science - Carnegie Mellon University |url=http://www.cmu.edu/mcs/about/awards/faculty/early-career.html |access-date=2024-04-29 |website=www.cmu.edu |language=en}}</ref><ref>{{Cite web |title=Speakers |url=https://nm2.epfl.ch/nm2-2019/speakers/ |access-date=2024-04-29 |website=EPFL |language=en-GB}}</ref><ref>{{Cite web |title=Connect with Faculty Expert Alison Barth - News - Carnegie Mellon University |url=https://www.cmu.edu/news/experts/alison.barth |access-date=2024-04-29 |website=www.cmu.edu |language=en}}</ref><ref>{{Cite web |date=2024-04-20 |title=Carnegie Mellon University Celebrates Five Faculty Elected as 2023 AAAS Fellows |url=https://indiaeducationdiary.in/carnegie-mellon-university-celebrates-five-faculty-elected-as-2023-aaas-fellows/ |access-date=2024-04-29 |website=India Education {{!}} Latest Education News {{!}} Global Educational News {{!}} Recent Educational News |language=en-US}}</ref><ref name=":5">{{Cite web |last=Opdyke |first=Heidi |date=April 18, 2024 |title=Barth, Tetali Elected 2023 AAAS Fellows |url=http://www.cmu.edu/mcs/news-events/2024/0418_aaas-fellows-announcement.html |access-date=2024-04-29 |website=www.cmu.edu |language=en}}</ref>. Barth was elected as one of the 2023 fellows of the [[American Association for the Advancement of Science]]<ref name=":5" />.

== Publications ==

* [https://pubmed.ncbi.nlm.nih.gov/34232978/ Barth, R.F., Buja, L.M., Barth, A.L., Carpenter, D.E., Parwani, A.V. A Comparison of the Clinical, Pathologic, Virologic, and Immunologic Features of SARS, MERS, and COVID-19 Viral Diseases. (2021) Archives of Pathology & Laboratory Medicine Oct 1;145(10):1194-1211. doi: 10.5858/arpa.2020-0820-SA.]
* [https://www.mendeley.com/catalogue/6745b6e6-3475-30f9-8229-a0d570b620a3/ Chandrasekaran, S., Navlakha, S., Audette, N.J., McCreary, D., Souhan, J., Bar-Joseph, Z., and Barth, A.L.  Unbiased, high-throughput analysis of experience-dependent changes in synaptic density in somatosensory cortex. (2015) Journal of Neuroscience Dec 16;35(50):16450-16462.]
* [https://www.cell.com/neuron/fulltext/S0896-6273(19)30394-0 Park, E., Audette, N.J. and Barth, A.L. Learning-dependent enhancement of persistent activity in the neocortex. (2021) 9th International Conference on Learning Representations (ICLR), Vienna Austria May 2021, Workshop Track Proceedings.]
* [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5618792/ Pratt, C.P., He, J., Wang, Y., Barth, A.L., and Bruchez, M.P.  Fluorogenic Green-Inside Red -Outside (GIRO) labeling reveals kinase-dependent control of BKalpha surface expression.  (2015) Bioconjugate Chemistry Sep 16;26(9):1963-71.]
* [https://pubmed.ncbi.nlm.nih.gov/34576197/ Kuljis, D.A., Micheva, K.D., Wegner, W., Bowman, R., LaBranche, M., Madison, D.V., Willig, K.I., and Barth, A.L. Gephyrin-lacking PV synapses on neocortical pyramidal neurons. (2021) International Journal of Molecular Sciences. Sep 17;22(18):10032. doi: 10.3390/ijms221810032.]
* [https://www.cell.com/neuron/fulltext/S0896-6273(19)31010-4 <nowiki>Cai, X.,  Huang, H., Kuzirian, M.S., Snyder, L.M., Matsushita, M., Lee, M.C., Furguson, C.,  Homanics, G.E., Barth, A.L., and Ross, S.E. Generation of a KOR-Cre knockin mouse strain to study cells involved in kappa opioid signaling (2015) Genesis Nov 17. doi: 10.1002/dvg.22910. [Epub ahead of print]</nowiki>]
* [[doi:10.1371/journal.pone.0232916|Bernhard, S.M., Lee, J., Erskine, A., Hires, S.A. and Barth, A.L. Automated home-cage training drives sensory association learning. (2020) PLoS One Dec 2;15(12):e0232916. doi: 10.1371/journal.pone.0232916.]]
* [https://www.researchgate.net/publication/347310543_An_automated_homecage_system_for_multiwhisker_detection_and_discrimination_learning_in_mice Bernhard, S.M., Lee, J., Zhu, M., Hsu, A., Erskine, A., Hires, S.A., and Barth, A.L. (2020). An automated homecage system for multiwhisker detection and discrimination learning in mice. BioRxiv 2020.04.27.063750.]
* [https://www.semanticscholar.org/paper/Transient-and-layer-specific-reduction-in-PV-during-Kuljis-Park/b9ab46d69e08ee0f935bd5879944579be8e5d785 Kuljis, D.A., Park, E., Myal, S.E., Clopath, C., and Barth, A.L. (2020). Transient and layer-specific reduction in neocortical PV inhibition during sensory association learning. BioRxiv 2020.04.24.059865.]
* [https://pubmed.ncbi.nlm.nih.gov/31619497/ Litvina, E., Adams, A., Barth, A.L., Bruchez, M.P., Carson, J., Dupre, K.B., Frank, L.M., Gates, K.M., Harris, K.M., Joo, H., Lichtman, J.W., Ramos, K.M., Sejnowski, T., Trimmer, J.S., White, S., Koroshetz, W. BRAIN Initiative: Cutting-edge tools and resources for the community. (2019) Journal of Neuroscience 16 October 39(42):8275-8284. doi: 10.1523/JNEUROSCI.1169-19.2019]
* [https://pubmed.ncbi.nlm.nih.gov/31600514/ Barth, A.L. and Ray, A. Progressive circuit changes during learning and disease. (2019) Neuron 9 October 104(1):37-46. doi: 10.1016/j.neuron.2019.09.032]
* [https://www.eneuro.org/content/6/5/ENEURO.0193-19.2019 Kuljis, D.A., Park, E., Telmer, C.A., Lee, J., Ackerman, D.S., Bruchez, M.P. and Barth, A.L. Fluorescence-based quantitative synapse analysis for cell-type specific connectomics. (2019) eNeuro 23 September. doi: 10.1523/ENEURO.0193-19.2019]
* Audette, N.J., Bernhard, S. M., Ray, A., Stewart, L.T., and Barth A.L. Rapid plasticity of higher-order thalamocortical inputs during sensory learning. Neuron. 2019 Jul 17;103(2):277-291.e4. doi: [[doi:10.1016/j.neuron.2019.02.037|10.1016/j.neuron.2019.04.037.]]
* Reddy, J.W., Kimukin, I., Ahmed, Z., Stewart, L., Barth, A.L., Towe, E. and Chamanzar, M. High density, double-sided, flexible optoelectrical neural probes with embedded micro-LEDs. Frontiers in Neuroscience, 09 August https://doi.org/10.3389/fnins.2019.00745
* Kuljis D.A., Zemoura K, Telmer C, Lee J, Park E, Xu W, Bruchez MP, and Barth AL. Quantitative synapse analysis for cell-type specific connectomics. BioRXiv, August 7, [[doi:10.1101/386912|10.1101/386912.]]
* [[doi:10.1002/cne.24418|Beukema P, Cecil KL, Peterson E, Mann VR, Matsushita M, Takashima Y, Navlakha S, and Barth AL. TrpM8-mediated somatosensation in mouse neocortex. Journal of Comparative Neurology, Jun 15, 526(9):1444-1456.]]
* [[doi:10.1016/j.tics.2017.09.012|Navlakha S, Bar-Joseph Z, and Barth AL. Network Design and the Brain. Trends in Cognitive Science, 22 Jan 2018.]]
* [[doi:10.1016/j.neuron.2018.01.037|Urban-Ciecko J, Jouhanneau JS, Myal SE, Poulet JFA, and Barth AL. Precisely Timed Nicotinic Activation Drives SST Inhibition in Neocortical Circuits. Neuron, 7 Feb 2018, 97(3): 611-625.]]
* [[doi:10.3389/fncel.2017.00337|Pratt CP, Kuljis DA, Homanics G, Dudem S, Hollywood MA, Barth AL, Bruchez MP. Tagging of endogenous BK channels with a fluorogen-activating peptide reveals β4-mediated control of channel clustering in cerebellum. Front Cell Neurosci., 31 Oct 2017, 11:337.]]
* [[doi:10.1016/j.neuron.2017.06.006|Lee J, Barth AL. Constructing the external world. Neuron, 21 Jun 2017, 94(6): 1048-1050.]]
* Audette NJ, Urban-Ciecko J, Matsushita M, Barth AL. POm thalamocortical input drives layer-specific microcircuits in somatosensory cortex. Cerebral Cortex, 10 Mar 2017, 1-17.
* Urban-Ciecko, J. and Barth A.L.  Somatostatin neurons in cortical networks (2016) Nature Reviews Neuroscience 17:401–409.
* Ye, L., Allen, W.F., Thompson, K.R., Tian, Q., Hsueh, B., Ramakrishnan, C., Wang A.-C., Jennings, J., Adhikari, A., Witten, I.B., Barth, A.L., Luo, L. Halpern C.H., McNab, J., and Deisseroth, K.  Long-range wiring and molecular signatures of prefrontal cortex neuronal populations mediating positive or negative valence experience.  (2016) Cell Jun 16;165(7):1776-88.
* Barth A., Burkhalter A., Callaway E.M., Connors B.W., Cauli B., DeFelipe J., Feldmeyer D., Freund T., Kawaguchi Y., Kisvarday Z ., Kubota Y., McBain C., Oberlaender M., Rossier J., Rudy B., Staiger J.F., Somogyi P., Tamas G., Yuste R. Comment on "Principles of connectivity among morphologically defined cell types in adult neocortex".  (2016) Science Sep 9;353(6304):1108.
* Navlakha, S., Barth, A.L.*, and Bar-Joseph, Z.* Synapse pruning rates optimize construction of efficient and robust networks. (2015) PLoS Computational Biology July 28; 11(7): e1004347.  *indicates co-corresponding authors
* Urban-Ciecko, J., Fanselow, E.E., and Barth, A.L.  Neocortical somatostatin neurons reversibly silence excitatory transmission via GABAb receptors (2015) Current Biology Mar 16;25(6):722-31.
* Glazewski, S. and Barth, A.L.  Stimulus intensity determines experience-dependent modifications in neocortical neuron firing rates. (2015) European Journal of Neuroscience Feb;41(4):410-9.
* Urban-Ciecko, J., Wen, J.A., Parekh, P.K., and Barth, A.L.  Experience-dependent regulation of presynaptic NMDARs enhances neurotransmitter release at neocortical synapses. (2014) Learning and Memory  Dec 15;22(1):47-55.
* Jouhanneau, J.S., Ferrarese, L., Estabanez L., Audette N., Brecht, M., Barth, A.L., and Poulet, J.F.A. Cortical cfos expression reveals broad receptive field excitatory neurons targeted by POm. (2014) Neuron Nov 13;84(5):1065-1078.
* Czajkowski, R., Jayaprakash, B., Wiltgen, B., Rogerson, T., Karlsson, M.G., Barth, A.L., Trachtenberg, J., and Silva, A.J.  Encoding and storage of spatial information in the retrosplenial cortex (2014) PNAS Jun 10;111(23):8661-6
* Barth, A.L. and Kuhlman, S.J.  The many layers of specification and plasticity in the neocortex. (2013) Neuron 79(5): 829-831.
* Navlakha, S., Suhan, J., Barth, A.L., and Bar-Joseph, Z.  A high-throughput machine learning framework to detect synapses in electron microscopy images. (2013)  Proc. of the 21st Intl. Conf. on Intelligent Systems for Molecular Biology and 12th European Conf. on Computational Biology (ISMB/ECCB). Bioinformatics. Jul 1;29(13):i9-17.
* Wen, J.A. and Barth, A.L.  Initiation, labile, and stabilization phases of experience-dependent plasticity at neocortical synapses.  (2013) Journal of Neuroscience 33(19):8483-93.
* Benedetti, B.L.*, Takashima, Y.*, Wen, J.A., Urban-Ciecko, J., and Barth, A.L.  Asymmetric wiring of layer 2/3 neurons drives sparse and reliable firing during neocortical development.  (2012) Cerebral Cortex Aug 23. [Epub ahead of print] *these authors contributed equally to this work.
* Poulet, J.F.A. and Barth, A.L. Experimental evidence for sparse firing in the neocortex. (2012) Trends in Neurosciences, Jun;35(6):345-55.
* Wen, J.A. and Barth A.L.  Synaptic lability after experience-dependent plasticity is not mediated by calcium-permeable AMPARs. (2012) Frontiers in Molecular Neuroscience 2012;5:15, epub 2012 Feb 29.
* Shruti, S., Urban-Ciecko, J, Fitzpatrick, J., Brenner, R., Bruchez, M., and Barth, A.L.  The brain-specific beta 4 subunit downregulates BK channel cell surface expression. (2012) PlosOne  2012;7(3):e33429, epub Mar 16.
* Barth, A.L.  AC-1 and synaptic development. (2012) Journal of Physiology 1;590(Pt 1):3.
* Ly, C., Melman, T. Barth, A.L. and Ermentrout, G.B.  Phase-resetting curve determines how BK currents affect neuronal firing. (2011) Journal of Computational Neuroscience Apr;30(2):211-23.
* Wen, J.A. and Barth, A.L.  Input-specific critical periods for experience-dependent plasticity in layer 2/3 pyramidal neurons. (2011) Journal of Neuroscience 23;31(12):4456-65.
* Yassin, L., Benedetti, B.L., Jouhanneau, J.-S., Wen, J.A., Poulet, J.F.A. and Barth A.L. An embedded subnetwork of highly active neurons in the neocortex. (2010) Neuron 68(6):1043-50.


== References ==
== References ==

Revision as of 14:56, 29 April 2024

Alison Barth is an American neuroscientist and the Maxwell H. and Gloria C. Connan Professor of Life Sciences, Biological Sciences and Neuroscience Institute at Carnegie Mellon University[1][2][3]. She is the founder and principal investigator of Barth Lab, where the research focus is understanding how experience assembles and alters the properties of neural circuits in the cerebral cortex, in both typical and disordered states[4][3].

Early life and education

Alison Barth was born in the state of Maryland, but her family later moved to the states of Kansas, Wisconsin, and Ohio throughout her childhood[3]. She attended Brown University for her undergraduate education, where she received a Bachelor of Arts in Biology (1991)[5]. She then moved to the West Coast of the United States where she received her Ph.D. in Molecular and Cell Biology from the University of California, Berkeley (1997), and conducted her post-doctoral research in neurophysiology at Stanford University (2001)[5][2][6].

Research and Career

During her time at Stanford University, Barth developed and filed a provisional patent for the “fosGFP” mouse, a transgenic mouse that labels green fluorescent protein (GFP) expression in vivo and visualizes neurons undergoing plasticity[7][2].

Barth then moved to Carnegie Mellon University in 2002, where she began teaching as a professor of Biological Sciences and Biomedical Engineering, eventually founding the Barth Lab[2][6]. Founder and principal investigator for Barth lab, Barth leads her team and focuses on understanding how experience assembles and alters the properties of neural circuits in the cerebral cortex, in both typical and disordered states[4].

Currently, Barth's research focuses on understanding how the brain changes in response to experience, particularly in the context of learning and memory[3][8]. She studies the somatosensory cortex of rodents, investigating how synapses are altered as animals undergo different types of experiences[3].

Barth's team has developed a tactile learning task for mice, where they stimulate the whiskers and then reward the animals with water to observe synaptic changes[3]. The goal is to identify the specific neural networks that are altered as the animals learn these associations[3]. By pinpointing the synapses involved in these learned behaviors, Barth aims to uncover the neural circuits crucial for forming these associations, shedding light on the mechanisms underlying learning and memory[3].

Honors and Awards

In 2012, she received the McKnight Foundation’s Memory and Cognitive Disorders Award[9]. In 2014, she received the Kaufman Grant to study neural communication in the cerebral cortex[10].

She was awarded the Society for Neuroscience’s Research Award for Innovation in Neuroscience and the Career Development Award in 2008, and she received the Humboldt Foundation’s Bessel Research Award as well in 2009[11][12][13][14][15][16]. Barth was elected as one of the 2023 fellows of the American Association for the Advancement of Science[16].

Publications

References

  1. ^ University, Carnegie Mellon. "Alison Barth - Neuroscience Institute - Carnegie Mellon University". www.cmu.edu. Retrieved 2024-04-28.
  2. ^ a b c d "Dr. Alison Barth". Stories of WiN. 2020-09-16. Retrieved 2024-04-29.
  3. ^ a b c d e f g h "Episode 30: Alison Barth, PhD". Conjugate: Illustration and Science Blog. Retrieved 2024-04-28.
  4. ^ a b "Barth Lab". Retrieved 2024-04-28.
  5. ^ a b "Alison L. Barth, Ph.D." www.isb.pitt.edu. Retrieved 2024-04-28.
  6. ^ a b Weigand, Jodi (February 6, 2010). "Newsmaker: Alison Barth". TribLive. Retrieved 2024-04-29.
  7. ^ "fosGFP Mouse: A Novel Transgenic Mouse for Identifying Subsets of Activated Cells | Explore Technologies". techfinder.stanford.edu. Retrieved 2024-04-29.
  8. ^ "Reflecting causality in synaptic changes | Sainsbury Wellcome Centre". www.sainsburywellcome.org. Retrieved 2024-04-29.
  9. ^ "Awardees". McKnight Foundation. Retrieved 2024-04-29.
  10. ^ "2021 Kaufman Initiative Research Award - Zhao and Barth | Charles E. Kaufman Foundation". kaufman.pittsburghfoundation.org. Retrieved 2024-04-29.
  11. ^ "Prof. Dr. Alison L. Barth". www.humboldt-foundation.de. Retrieved 2024-04-29.
  12. ^ University, Carnegie Mellon. "Early Career Awards - Mellon College of Science - Carnegie Mellon University". www.cmu.edu. Retrieved 2024-04-29.
  13. ^ "Speakers". EPFL. Retrieved 2024-04-29.
  14. ^ "Connect with Faculty Expert Alison Barth - News - Carnegie Mellon University". www.cmu.edu. Retrieved 2024-04-29.
  15. ^ "Carnegie Mellon University Celebrates Five Faculty Elected as 2023 AAAS Fellows". India Education | Latest Education News | Global Educational News | Recent Educational News. 2024-04-20. Retrieved 2024-04-29.
  16. ^ a b Opdyke, Heidi (April 18, 2024). "Barth, Tetali Elected 2023 AAAS Fellows". www.cmu.edu. Retrieved 2024-04-29.
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