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{{Infobox scientist
{{Orphan|date=April 2019}}
| name = Vivian Li

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{{Infobox scientist
| name = Vivian Li
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| spouse = William Berry
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| fields = [[Gastrointestinal tract|Bowel]] cancer development, [[Organoids]]
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| spouse = William Berry
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| workplaces = {{Plainlist|
| citizenship =
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* [[University of Hong Kong]]
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| fields = [[Gastrointestinal tract|Bowel]] cancer development, [[Organoids]]
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| workplaces = {{Plainlist|
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* [[University of Hong Kong]]
* [[Hubrecht Institute]]
* [[Hubrecht Institute]]
*[[National Institute for Medical Research]]
* [[National Institute for Medical Research]]
*[[Francis Crick Institute]]}}
* [[Francis Crick Institute]]}}
| alma_mater = Chinese University of Hong Kong
| alma_mater = Chinese University of Hong Kong
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| thesis_year = 2008
| thesis_year = 2008
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| known_for = Developmental biology, Organoids
| known_for = Developmental biology, Organoids
| awards = Future Leaders in Cancer Research Prize, Cancer Research UK
| awards = Future Leaders in Cancer Research Prize, Cancer Research UK
| signature =
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'''Vivian Li''' is a [[Hong Kong]]-born cell and developmental biologist working in [[cancer]] research at London's [[Francis Crick Institute]]. She has been researching how [[stem cell]]s in the human [[Gastrointestinal tract|bowel]] are programmed to ensure a healthy organ and what goes wrong when cancer develops.<ref name="Vivian">{{Cite web|url=https://www.crick.ac.uk/research/labs/vivian-li|title=Vivian Li|website=Crick|language=en|access-date=2019-03-07}}</ref> She is known for her work on the [[Wnt signalling pathway]], discovering a new way that a molecule called [[Wnt]] is activated in bowel cancer.<ref name="Wnt">{{Cite journal|last=Novellasdemunt|first=Laura|last2=Foglizzo|first2=Valentina|last3=Cuadrado|first3=Laura|last4=Antas|first4=Pedro|last5=Kucharska|first5=Anna|last6=Encheva|first6=Vesela|last7=Snijders|first7=Ambrosius P.|last8=Li|first8=Vivian S. W.|date=2017-10-17|title=USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination|journal=Cell Reports|volume=21|issue=3|pages=612–627|doi=10.1016/j.celrep.2017.09.072|issn=2211-1247|pmc=5656747|pmid=29045831}}</ref> She won a Future Leaders in Cancer Research Prize in part for this discovery.<ref name="award">{{Cite web|url=https://www.cancerresearchuk.org/funding-for-researchers/research-features/2018-12-06-celebrating-a-lifetime-in-cancer-biology-an-early-diagnosis-champion-and-our-leaders-of-tomorrow-the|title=Celebrating a lifetime in cancer biology, an early diagnosis champion, and our leaders of tomorrow: the 2018 CRUK Research Prizes|date=2018-12-06|website=Cancer Research UK|language=en|access-date=2019-03-07}}</ref>
'''Vivian Li''' is a [[Hong Kong]]-born cell and developmental biologist working in [[cancer]] research at London's [[Francis Crick Institute]]. She has been researching how [[stem cell]]s in the human [[Gastrointestinal tract|bowel]] are programmed to ensure a healthy organ and what goes wrong when cancer develops.<ref name="Vivian">{{Cite web |url=https://www.crick.ac.uk/research/labs/vivian-li |title=Vivian Li |website=Crick |access-date=2019-03-07}}</ref> She is known for her work on the [[Wnt signalling pathway]], discovering a new way that a molecule called [[Wnt]] is activated in bowel cancer.<ref name="Wnt">{{Cite journal |last=Novellasdemunt |first=Laura |last2=Foglizzo |first2=Valentina |last3=Cuadrado |first3=Laura |last4=Antas |first4=Pedro |last5=Kucharska |first5=Anna |last6=Encheva |first6=Vesela |last7=Snijders |first7=Ambrosius P. |last8=Li |first8=Vivian S. W. |date=2017-10-17 |title=USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination |journal=Cell Reports |volume=21 |issue=3 |pages=612–627 |doi=10.1016/j.celrep.2017.09.072 |issn=2211-1247 |pmc=5656747 |pmid=29045831}}</ref> She won a Future Leaders in Cancer Research Prize in part for this discovery.<ref name="award">{{Cite web |url=https://www.cancerresearchuk.org/funding-for-researchers/research-features/2018-12-06-celebrating-a-lifetime-in-cancer-biology-an-early-diagnosis-champion-and-our-leaders-of-tomorrow-the |title=Celebrating a lifetime in cancer biology, an early diagnosis champion, and our leaders of tomorrow: the 2018 CRUK Research Prizes |date=2018-12-06 |website=Cancer Research UK |access-date=2019-03-07}}</ref>


== Education and early career ==
== Education and early career ==
Li studied molecular biotechnology at the [[Chinese University of Hong Kong]] from 2000 to 2003, focusing on plant biotech in her final year. She then pursued a PhD in pathology at the [[University of Hong Kong]], awarded in 2008.<ref name="PhD">[https://www.gradsch.hku.hk/gradsch/current-students/awards-prizes/award-for-outstanding-research-postgraduate-student "Award for Outstanding Research Postgraduate Student"], ''The University of Hong Kong''</ref> After her PhD Li spent a few years working under [[Hans Clevers]]' at the [[Hubrecht Institute]] in the Netherlands.
Li studied molecular biotechnology at the [[Chinese University of Hong Kong]] from 2000 to 2003, focusing on plant biotech in her final year. She then pursued a PhD in pathology at the [[University of Hong Kong]], awarded in 2008.<ref name="PhD">[https://www.gradsch.hku.hk/gradsch/current-students/awards-prizes/award-for-outstanding-research-postgraduate-student "Award for Outstanding Research Postgraduate Student"], The University of Hong Kong</ref> After her PhD Li spent a few years working under [[Hans Clevers]]' at the [[Hubrecht Institute]] in the Netherlands.


Li became a group leader in 2013, setting up her laboratory at the MRC's [[National Institute for Medical Research]] (now part of the [[Francis Crick Institute]]. She was appointed a group leader at the Francis Crick Institute in April 2015.<ref name="Vivian"/>
Li became a group leader in 2013, setting up her laboratory at the MRC's [[National Institute for Medical Research]] (now part of the [[Francis Crick Institute]]. She was appointed a group leader at the Francis Crick Institute in April 2015.<ref name="Vivian" />


== Research ==
== Research ==
Li's research team has used the bowel as a model to study how stem cells help maintain a healthy organ, and what goes wrong when cancer develops. She's focused her career on a particular signalling pathway that helps stem cells grow and multiply properly, called Wnt. Overactive Wnt signalling is associated with many bowel cancers by causing stem cells to divide too quickly.
Li's research team has used the bowel as a model to study how stem cells help maintain a healthy organ, and what goes wrong when cancer develops. She's focused her career on a particular signalling pathway that helps stem cells grow and multiply properly, called Wnt. Overactive Wnt signalling is associated with many bowel cancers by causing stem cells to divide too quickly.


Li's lab have used a variety of models, including an innovative [[organoid]] system, to reveal a new way that a molecule called Wnt is activated in bowel cancer.<ref name="Wnt"/><ref>{{Cite web|url=https://www.crick.ac.uk/news/2018-11-07_leading-the-future-of-cancer-research|title=Leading the future of cancer research|website=Crick|language=en|access-date=2019-03-07}}</ref> Li's work has offered the prospect of targeted treatment of tumour cells without toxic effects on healthy cells.<ref name="Lansdowne-17Dec2018">{{cite news |last1=Lansdowne |first1=Laura Elizabeth |title=Cell Signaling in Cancer |url=https://www.technologynetworks.com/cancer-research/articles/cell-signaling-in-cancer-313171 |accessdate=7 March 2019 |work=Technology Networks |date=17 December 2018}}</ref><ref name="Atherton-18Oct2017">{{cite news |last1=Atherton |first1=Matt |title=Bowel cancer BREAKTHROUGH: New treatment is first non-toxic therapy |url=https://www.express.co.uk/life-style/health/868084/Bowel-cancer-BREAKTHROUGH-treatment-toxic-therapy |accessdate=7 March 2019 |work=Express |date=18 October 2017}}</ref> This discovery was one of the reasons that she won a Future Leaders in Cancer Research Prize in 2018.<ref name="award"/> Research like this could help scientists to develop more targeted treatments for bowel cancer in the future.
Li's lab have used a variety of models, including an innovative [[organoid]] system, to reveal a new way that a molecule called Wnt is activated in bowel cancer.<ref name="Wnt" /><ref>{{Cite web |url=https://www.crick.ac.uk/news/2018-11-07_leading-the-future-of-cancer-research |title=Leading the future of cancer research |website=Crick |access-date=2019-03-07}}</ref> Li's work has offered the prospect of targeted treatment of tumour cells without toxic effects on healthy cells.<ref name="Lansdowne-17Dec2018">{{cite news |last1=Lansdowne |first1=Laura Elizabeth |title=Cell Signaling in Cancer |url=https://www.technologynetworks.com/cancer-research/articles/cell-signaling-in-cancer-313171 |accessdate=7 March 2019 |work=Technology Networks |date=17 December 2018}}</ref><ref name="Atherton-18Oct2017">{{cite news |last1=Atherton |first1=Matt |title=Bowel cancer BREAKTHROUGH: New treatment is first non-toxic therapy |url=https://www.express.co.uk/life-style/health/868084/Bowel-cancer-BREAKTHROUGH-treatment-toxic-therapy |accessdate=7 March 2019 |work=Express |date=18 October 2017}}</ref> This discovery was one of the reasons that she won a Future Leaders in Cancer Research Prize in 2018.<ref name="award" /> Research like this could help scientists to develop more targeted treatments for bowel cancer in the future.


Li's work in growing intestinal cells in a laboratory at the Francis Crick Institute has benefited from the Institute's proximity to hospitals such as [[Great Ormond Street Hospital]].<ref name="Davis-17Feb2016">{{cite news |last1=Davis |first1=Nicola |title=Meet the researchers at London’s £700m altar to biomedical science |url=https://www.theguardian.com/science/2016/feb/17/meet-the-researchers-at-londons-700m-altar-to-biomedical-science |accessdate=7 March 2019 |work=Guardian |date=17 February 2016}}</ref> Li was listed as a ‘scientist to watch’ in an article on the rising stars of culture, science and food in 2019 in ''[[The Observer]]''.<ref>{{Cite news|url=https://www.theguardian.com/culture/2019/jan/06/the-observer-rising-stars-of-2019-film-music-art-activism-food-books|title=New talent: the rising stars of culture, science and food 2019|last=Staff|first=Guardian|date=2019-01-06|work=The Observer|access-date=2019-03-07|language=en-GB|issn=0029-7712}}</ref>
Li's work in growing intestinal cells in a laboratory at the Francis Crick Institute has benefited from the Institute's proximity to hospitals such as [[Great Ormond Street Hospital]].<ref name="Davis-17Feb2016">{{cite news |last1=Davis |first1=Nicola |title=Meet the researchers at London’s £700m altar to biomedical science |url=https://www.theguardian.com/science/2016/feb/17/meet-the-researchers-at-londons-700m-altar-to-biomedical-science |accessdate=7 March 2019 |work=The Guardian |date=17 February 2016}}</ref> Li was listed as a ‘scientist to watch’ in an article on the rising stars of culture, science and food in 2019 in ''[[The Observer]]''.<ref>{{Cite news |url=https://www.theguardian.com/culture/2019/jan/06/the-observer-rising-stars-of-2019-film-music-art-activism-food-books |title=New talent: the rising stars of culture, science and food 2019 |last=Staff |first=Guardian |date=2019-01-06 |work=The Observer |access-date=2019-03-07 |issn=0029-7712}}</ref>


Li aims to use her expertise in growing intestines in the lab to improve organ transplantation in the future.<ref name="Davis-17Feb2016"/>
Li aims to use her expertise in growing intestines in the lab to improve organ transplantation in the future.<ref name="Davis-17Feb2016" />


== Awards and honours ==
== Awards and honours ==
*Gold Medal Prize for PhD thesis.<ref name="PhD"/> The prize is given to PhD candidates who have submitted work of "exceptional quality" and demonstrated excellence in other academic pursuits.
* Gold Medal Prize for PhD thesis.<ref name="PhD" /> The prize is given to PhD candidates who have submitted work of "exceptional quality" and demonstrated excellence in other academic pursuits.
*Croucher Foundation Fellowship to study at the [[Hubrecht Institute]]<ref>{{Cite web|url=https://croucher.org.hk/dr-vivian-li-on-contributing-her-piece-to-the-puzzle-of-science|title=Dr Vivian Li on contributing her piece to the puzzle of science {{!}} Croucher Foundation|language=en-US|access-date=2019-03-07}}</ref>
* Croucher Foundation Fellowship to study at the [[Hubrecht Institute]]<ref>{{Cite web |url=https://croucher.org.hk/dr-vivian-li-on-contributing-her-piece-to-the-puzzle-of-science |title=Dr Vivian Li on contributing her piece to the puzzle of science {{!}} Croucher Foundation|access-date=2019-03-07}}</ref>
*2018 Future Leaders in Cancer Research Prize by [[Cancer Research UK]],<ref name="award"/> awarded to individuals with potential to become international research leaders<ref>[https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/our-research-prizes/future-leaders-in-cancer-research-prize "Future Leaders in Cancer Research Prize"], ''Cancer Research UK''</ref>
* 2018 Future Leaders in Cancer Research Prize by [[Cancer Research UK]],<ref name="award" /> awarded to individuals with potential to become international research leaders<ref>[https://www.cancerresearchuk.org/funding-for-researchers/how-we-deliver-research/our-research-prizes/future-leaders-in-cancer-research-prize "Future Leaders in Cancer Research Prize"], ''Cancer Research UK''</ref>


== References ==
== References ==

Revision as of 14:35, 2 April 2019

Vivian Li
Alma materChinese University of Hong Kong
Known forDevelopmental biology, Organoids
SpouseWilliam Berry
AwardsFuture Leaders in Cancer Research Prize, Cancer Research UK
Scientific career
FieldsBowel cancer development, Organoids
Institutions
Thesis (2008)

Vivian Li is a Hong Kong-born cell and developmental biologist working in cancer research at London's Francis Crick Institute. She has been researching how stem cells in the human bowel are programmed to ensure a healthy organ and what goes wrong when cancer develops.[1] She is known for her work on the Wnt signalling pathway, discovering a new way that a molecule called Wnt is activated in bowel cancer.[2] She won a Future Leaders in Cancer Research Prize in part for this discovery.[3]

Education and early career

Li studied molecular biotechnology at the Chinese University of Hong Kong from 2000 to 2003, focusing on plant biotech in her final year. She then pursued a PhD in pathology at the University of Hong Kong, awarded in 2008.[4] After her PhD Li spent a few years working under Hans Clevers' at the Hubrecht Institute in the Netherlands.

Li became a group leader in 2013, setting up her laboratory at the MRC's National Institute for Medical Research (now part of the Francis Crick Institute. She was appointed a group leader at the Francis Crick Institute in April 2015.[1]

Research

Li's research team has used the bowel as a model to study how stem cells help maintain a healthy organ, and what goes wrong when cancer develops. She's focused her career on a particular signalling pathway that helps stem cells grow and multiply properly, called Wnt. Overactive Wnt signalling is associated with many bowel cancers by causing stem cells to divide too quickly.

Li's lab have used a variety of models, including an innovative organoid system, to reveal a new way that a molecule called Wnt is activated in bowel cancer.[2][5] Li's work has offered the prospect of targeted treatment of tumour cells without toxic effects on healthy cells.[6][7] This discovery was one of the reasons that she won a Future Leaders in Cancer Research Prize in 2018.[3] Research like this could help scientists to develop more targeted treatments for bowel cancer in the future.

Li's work in growing intestinal cells in a laboratory at the Francis Crick Institute has benefited from the Institute's proximity to hospitals such as Great Ormond Street Hospital.[8] Li was listed as a ‘scientist to watch’ in an article on the rising stars of culture, science and food in 2019 in The Observer.[9]

Li aims to use her expertise in growing intestines in the lab to improve organ transplantation in the future.[8]

Awards and honours

  • Gold Medal Prize for PhD thesis.[4] The prize is given to PhD candidates who have submitted work of "exceptional quality" and demonstrated excellence in other academic pursuits.
  • Croucher Foundation Fellowship to study at the Hubrecht Institute[10]
  • 2018 Future Leaders in Cancer Research Prize by Cancer Research UK,[3] awarded to individuals with potential to become international research leaders[11]

References

  1. ^ a b "Vivian Li". Crick. Retrieved 2019-03-07.
  2. ^ a b Novellasdemunt, Laura; Foglizzo, Valentina; Cuadrado, Laura; Antas, Pedro; Kucharska, Anna; Encheva, Vesela; Snijders, Ambrosius P.; Li, Vivian S. W. (2017-10-17). "USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination". Cell Reports. 21 (3): 612–627. doi:10.1016/j.celrep.2017.09.072. ISSN 2211-1247. PMC 5656747. PMID 29045831.
  3. ^ a b c "Celebrating a lifetime in cancer biology, an early diagnosis champion, and our leaders of tomorrow: the 2018 CRUK Research Prizes". Cancer Research UK. 2018-12-06. Retrieved 2019-03-07.
  4. ^ a b "Award for Outstanding Research Postgraduate Student", The University of Hong Kong
  5. ^ "Leading the future of cancer research". Crick. Retrieved 2019-03-07.
  6. ^ Lansdowne, Laura Elizabeth (17 December 2018). "Cell Signaling in Cancer". Technology Networks. Retrieved 7 March 2019.
  7. ^ Atherton, Matt (18 October 2017). "Bowel cancer BREAKTHROUGH: New treatment is first non-toxic therapy". Express. Retrieved 7 March 2019.
  8. ^ a b Davis, Nicola (17 February 2016). "Meet the researchers at London's £700m altar to biomedical science". The Guardian. Retrieved 7 March 2019.
  9. ^ Staff, Guardian (2019-01-06). "New talent: the rising stars of culture, science and food 2019". The Observer. ISSN 0029-7712. Retrieved 2019-03-07.
  10. ^ "Dr Vivian Li on contributing her piece to the puzzle of science | Croucher Foundation". Retrieved 2019-03-07.
  11. ^ "Future Leaders in Cancer Research Prize", Cancer Research UK
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