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In [[molecular biology]], '''miR-130 microRNA precursor''' is a small [[non-coding RNA]] that regulates [[gene expression]]. This [[microRNA]] has been identified in [[mouse]] ([http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000156 MI0000156], [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000408 MI0000408]),<ref>{{cite journal | last = Lagos-Quintana | first = M |author2=Rauhut R |author3=Yalcin A |author4=Meyer J |author5=Lendeckel W |author6=Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735&ndash;739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6 | issue = 9}}</ref> and in [[human]] ([http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000448 MI0000448], [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000748 MI0000748]).<ref>{{cite journal | last = Houbaviy | first = HB |author2=Murray MF |author3=Sharp PA | year = 2003 | title = Embryonic stem cell-specific MicroRNAs | journal = Dev Cell | volume = 5 | pages = 351&ndash;358 | pmid = 12919684 | doi = 10.1016/S1534-5807(03)00227-2 | issue = 2}}</ref> miR-130 appears to be vertebrate-specific [[microRNA|miRNA]] and has now been predicted or experimentally confirmed in a range of vertebrate species ([http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 MIPF0000034]). Mature microRNAs are processed from the precursor [[stem-loop]] by the [[Dicer]] enzyme. In this case, the mature sequence is excised from the 3' arm of the [[stem-loop|hairpin]]. It has been found that miR-130 is upregulated in a type of [[cancer]] called [[hepatocellular carcinoma]].<ref name="pmid16924677">{{cite journal |vauthors=Kutay H, Bai S, Datta J, etal | title = Downregulation of miR-122 in the rodent and human hepatocellular carcinomas | journal = J. Cell. Biochem. | volume = 99 | issue = 3 | pages = 671–8 | year = 2006 | pmid = 16924677 | doi = 10.1002/jcb.20982 | pmc=3033198}}</ref> It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.<ref name=" pmid = 20402329 ">{{cite journal |vauthors=Escobar G, Moi D, Ranghetti A, etal | title = Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression. | journal = Sci Transl Med. | volume = 6 | issue = 217 |date=Jan 2014 | pmid = 24382895 | url = http://stm.sciencemag.org/content/6/217/217ra3.short | pages = 217 | doi=10.1126/scitranslmed.3006353}}</ref>
In [[molecular biology]], '''miR-130 microRNA precursor''' is a small [[non-coding RNA]] that regulates [[gene expression]]. This [[microRNA]] has been identified in [[mouse]] ([https://archive.is/20121223195009/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000156 MI0000156], [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000408 MI0000408]{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}),<ref>{{cite journal | last = Lagos-Quintana | first = M |author2=Rauhut R |author3=Yalcin A |author4=Meyer J |author5=Lendeckel W |author6=Tuschl T | year = 2002 | title = Identification of tissue-specific microRNAs from mouse | journal = Curr Biol | volume = 12 | pages = 735&ndash;739 | pmid = 12007417 | doi = 10.1016/S0960-9822(02)00809-6 | issue = 9}}</ref> and in [[human]] ([https://archive.is/20121223040017/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000448 MI0000448], [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_entry.pl?acc=MI0000748 MI0000748]{{dead link|date=February 2018 |bot=InternetArchiveBot |fix-attempted=yes }}).<ref>{{cite journal | last = Houbaviy | first = HB |author2=Murray MF |author3=Sharp PA | year = 2003 | title = Embryonic stem cell-specific MicroRNAs | journal = Dev Cell | volume = 5 | pages = 351&ndash;358 | pmid = 12919684 | doi = 10.1016/S1534-5807(03)00227-2 | issue = 2}}</ref> miR-130 appears to be vertebrate-specific [[microRNA|miRNA]] and has now been predicted or experimentally confirmed in a range of vertebrate species ([https://archive.is/20121223051101/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 MIPF0000034]). Mature microRNAs are processed from the precursor [[stem-loop]] by the [[Dicer]] enzyme. In this case, the mature sequence is excised from the 3' arm of the [[stem-loop|hairpin]]. It has been found that miR-130 is upregulated in a type of [[cancer]] called [[hepatocellular carcinoma]].<ref name="pmid16924677">{{cite journal |vauthors=Kutay H, Bai S, Datta J, etal | title = Downregulation of miR-122 in the rodent and human hepatocellular carcinomas | journal = J. Cell. Biochem. | volume = 99 | issue = 3 | pages = 671–8 | year = 2006 | pmid = 16924677 | doi = 10.1002/jcb.20982 | pmc=3033198}}</ref> It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.<ref name=" pmid = 20402329 ">{{cite journal |vauthors=Escobar G, Moi D, Ranghetti A, etal | title = Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression. | journal = Sci Transl Med. | volume = 6 | issue = 217 |date=Jan 2014 | pmid = 24382895 | url = http://stm.sciencemag.org/content/6/217/217ra3.short | pages = 217 | doi=10.1126/scitranslmed.3006353}}</ref>


==References==
==References==
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==External links==
==External links==
* {{Rfam|id=RF00258|name=mir-130 microRNA precursor family}}
* {{Rfam|id=RF00258|name=mir-130 microRNA precursor family}}
* [http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 miRBase family MIPF0000034]
* [https://archive.is/20121223051101/http://microrna.sanger.ac.uk/cgi-bin/sequences/mirna_summary.pl?fam=MIPF0000034 miRBase family MIPF0000034]


{{miRNA precursor families}}
{{miRNA precursor families}}

Revision as of 18:24, 1 February 2018

mir-130 microRNA precursor family
Predicted secondary structure and sequence conservation of mir-130
Identifiers
Symbolmir-130
RfamRF00258
miRBaseMI0000448
miRBase familyMIPF0000034
Other data
RNA typeGene; miRNA
Domain(s)Eukaryota
GOGO:0035195 GO:0035068
SOSO:0001244
PDB structuresPDBe

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408[permanent dead link]),[1] and in human (MI0000448, MI0000748[permanent dead link]).[2] miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma.[3] It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.[4]

References

  1. ^ Lagos-Quintana, M; Rauhut R; Yalcin A; Meyer J; Lendeckel W; Tuschl T (2002). "Identification of tissue-specific microRNAs from mouse". Curr Biol. 12 (9): 735–739. doi:10.1016/S0960-9822(02)00809-6. PMID 12007417.
  2. ^ Houbaviy, HB; Murray MF; Sharp PA (2003). "Embryonic stem cell-specific MicroRNAs". Dev Cell. 5 (2): 351–358. doi:10.1016/S1534-5807(03)00227-2. PMID 12919684.
  3. ^ Kutay H, Bai S, Datta J, et al. (2006). "Downregulation of miR-122 in the rodent and human hepatocellular carcinomas". J. Cell. Biochem. 99 (3): 671–8. doi:10.1002/jcb.20982. PMC 3033198. PMID 16924677.
  4. ^ Escobar G, Moi D, Ranghetti A, et al. (Jan 2014). "Genetic engineering of hematopoiesis for targeted IFN-α delivery inhibits breast cancer progression". Sci Transl Med. 6 (217): 217. doi:10.1126/scitranslmed.3006353. PMID 24382895.

External links



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