Nimetazepam: Difference between revisions
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'''Nimetazepam''' (marketed under brand name '''Erimin''') is a [[hypnotic]] drug which is a [[benzodiazepine]] derivative. It possesses strong [[hypnotic]], [[anxiolytic]], [[sedative]], and [[skeletal muscle relaxant]] properties. Nimetazepam is also a particularly potent [[anticonvulsant]].<ref>{{cite journal |author=Fukinaga M |coauthors=Ishizawa K, Kamei C. |year=1998 |month=Nov |title=Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action.|url=http://www.ncbi.nlm.nih.gov/pubmed/9742288?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|journal=Pharmacology |volume=5 |issue=57 |pages=233–41 |pmid=9742288}}</ref> It is sold in 5 mg tablets known as Erimin-5. It is used to treat [[insomnia]]. |
'''Nimetazepam''' (marketed under brand name '''Erimin''') is a [[hypnotic]] drug which is a [[benzodiazepine]] derivative. It possesses strong [[hypnotic]], [[anxiolytic]], [[sedative]], and [[skeletal muscle relaxant]] properties. Nimetazepam is also a particularly potent [[anticonvulsant]].<ref>{{cite journal |author=Fukinaga M |coauthors=Ishizawa K, Kamei C. |year=1998 |month=Nov |title=Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action.|url=http://www.ncbi.nlm.nih.gov/pubmed/9742288?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum|journal=Pharmacology |volume=5 |issue=57 |pages=233–41 |pmid=9742288}}</ref> It is sold in 5 mg tablets known as Erimin-5. It is used to treat [[insomnia]]. |
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Nimetazepam has a reputation for being particularly subject to abuse (known as 'Happy 5', sold as an Ecstasy replacement without a hangover), especially by persons addicted to [[amphetamines]] or [[opiates]]. For this reason it is no longer sold in most Western nations, but is still a significant drug of abuse in some Asian countries such as [[Japan]] and [[Malaysia]]. |
Nimetazepam has a reputation for being particularly subject to abuse (known as 'Happy 5', sold as an Ecstasy replacement without a hangover), especially by persons addicted to [[amphetamines]] or [[opiates]]. For this reason it is no longer sold in most Western nations, but is still a significant drug of abuse in some Asian countries such as [[Japan]] and [[Malaysia]]. Nimetazepam is subject to legal restrictions in Malaysia, and due to its scarcity, many tablets sold on the black market are in fact counterfeits containing other benzodiazepines such as [[diazepam]] or [[nitrazepam]] instead. Diazepam and nitrazepam are among the most widely prescribed benzodiazepines in the region, and as a result, they're commonly diverted and encountered on the black market. They usually end up on the black market as a result of being passed off as nimetazepam, temazepam or triazolam.<ref>[http://www.usdoj.gov/dea/programs/forensicsci/microgram/journal2004/page27.html DEA Resources, Microgram Journal, Volume 2, Numbers 1-4, January-December 2004<!-- Bot generated title -->]</ref> |
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In [[Singapore]], nimetazepam is a [[Misuse_of_Drugs_Act_(Singapore)#Class_A_-_Part_I|Class A-Schedule I controlled drug]], along with one other benzodiazepine: [[temazepam]]. The illegal distribution of nimetazepam may be punishable by death. Possession of the drug without a valid prescription from a registered medical doctor is illegal and punishable by extremely long prison terms. |
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In [[Hong Kong]], nimetazepam is regulated under Schedule 1 of [[Hong Kong|Hong Kong's]] Chapter 134 ''Dangerous Drugs Ordinance''. Nimetazepam can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 ([[Hong Kong dollar|HKD]]) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.<ref>{{cite web |title=Bilingual Laws Information System |url=http://www.legislation.gov.hk/eng/index.htm |format=English |publisher=The Government of the Hong Kong Special Administrative Region of the People's Republic of China}}</ref> |
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| ⚫ | In a rat study Nimetazepam showed greater damage to the fetus, as did [[nitrazepam]] and |
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| ⚫ | In [[Japan]], where seizures of diverted nimetazepam are mostly concentrated, it remains as a major drug of abuse. Seizures of the drug in [[Thailand]], [[Malaysia]], [[Singapore]], [[Laos]], [[Hong Kong]], and [[Indonesia]] are also common. The drug is usually exported from Japan, where the drug is legal by prescription for insomnia. Japanese organized crime syndicates control the distrubtion of nimetazepam and to a lesser extent, [[flutoprazepam]], [[temazepam]], [[midazolam]], and [[triazolam]], all of which are the most heavily controlled and most in demand benzodiazepines throughout [[East Asia]] and [[Southeast Asia]].<ref>Devaney, M., Reid, G. and Baldwin, S., 2006. Situational analysis of illicit drug issues and responses in the Asia-Pacific region, Research Paper 12. Australian National Council on Drugs, Canberra.</ref> |
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| ⚫ | In a rat study Nimetazepam showed greater damage to the fetus, as did [[nitrazepam]] and [[temazepam]] when compared against other benzodiazepines. Diazepam however showed relatively weak fetal toxicities. Temazepam was showed the greatest fetal toxicities among all common benzodiazepines.<ref>{{cite journal | author = Saito H | coauthors = Kobayashi H, Takeno S, Sakai T. | year = 1984 | title = Fetal toxicity of benzodiazepines in rats. | journal = Res Commun Chem Pathol Pharmacol. | volume = 46 | issue = 3 | pages = 437–47 | pmid = 6151222 }}</ref> |
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==See also== |
==See also== |
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Revision as of 23:05, 25 April 2008
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| Clinical data | |
|---|---|
| Pregnancy category |
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| Routes of administration | Oral |
| ATC code | |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | Hepatic |
| Elimination half-life | ? |
| Excretion | Renal |
| Identifiers | |
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| CAS Number | |
| PubChem CID | |
| DrugBank | |
| CompTox Dashboard (EPA) | |
| ECHA InfoCard | 100.016.302 |
| Chemical and physical data | |
| Formula | C16H13N3O3 |
| Molar mass | 295.3 g·mol−1 |
Nimetazepam (marketed under brand name Erimin) is a hypnotic drug which is a benzodiazepine derivative. It possesses strong hypnotic, anxiolytic, sedative, and skeletal muscle relaxant properties. Nimetazepam is also a particularly potent anticonvulsant.[1] It is sold in 5 mg tablets known as Erimin-5. It is used to treat insomnia.
Nimetazepam has a reputation for being particularly subject to abuse (known as 'Happy 5', sold as an Ecstasy replacement without a hangover), especially by persons addicted to amphetamines or opiates. For this reason it is no longer sold in most Western nations, but is still a significant drug of abuse in some Asian countries such as Japan and Malaysia. Nimetazepam is subject to legal restrictions in Malaysia, and due to its scarcity, many tablets sold on the black market are in fact counterfeits containing other benzodiazepines such as diazepam or nitrazepam instead. Diazepam and nitrazepam are among the most widely prescribed benzodiazepines in the region, and as a result, they're commonly diverted and encountered on the black market. They usually end up on the black market as a result of being passed off as nimetazepam, temazepam or triazolam.[2]
In Singapore, nimetazepam is a Class A-Schedule I controlled drug, along with one other benzodiazepine: temazepam. The illegal distribution of nimetazepam may be punishable by death. Possession of the drug without a valid prescription from a registered medical doctor is illegal and punishable by extremely long prison terms.
In Hong Kong, nimetazepam is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Nimetazepam can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.[3]
In Japan, where seizures of diverted nimetazepam are mostly concentrated, it remains as a major drug of abuse. Seizures of the drug in Thailand, Malaysia, Singapore, Laos, Hong Kong, and Indonesia are also common. The drug is usually exported from Japan, where the drug is legal by prescription for insomnia. Japanese organized crime syndicates control the distrubtion of nimetazepam and to a lesser extent, flutoprazepam, temazepam, midazolam, and triazolam, all of which are the most heavily controlled and most in demand benzodiazepines throughout East Asia and Southeast Asia.[4]
In a rat study Nimetazepam showed greater damage to the fetus, as did nitrazepam and temazepam when compared against other benzodiazepines. Diazepam however showed relatively weak fetal toxicities. Temazepam was showed the greatest fetal toxicities among all common benzodiazepines.[5]
See also
References
- ^ Fukinaga M (1998). "Anticonvulsant properties of 1,4-benzodiazepine derivatives in amygdaloid-kindled seizures and their chemical structure-related anticonvulsant action". Pharmacology. 5 (57): 233–41. PMID 9742288.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help); Unknown parameter|month=ignored (help) - ^ DEA Resources, Microgram Journal, Volume 2, Numbers 1-4, January-December 2004
- ^ "Bilingual Laws Information System" (English). The Government of the Hong Kong Special Administrative Region of the People's Republic of China.
- ^ Devaney, M., Reid, G. and Baldwin, S., 2006. Situational analysis of illicit drug issues and responses in the Asia-Pacific region, Research Paper 12. Australian National Council on Drugs, Canberra.
- ^ Saito H (1984). "Fetal toxicity of benzodiazepines in rats". Res Commun Chem Pathol Pharmacol. 46 (3): 437–47. PMID 6151222.
{{cite journal}}: Unknown parameter|coauthors=ignored (|author=suggested) (help)
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