User contributions for GrumpyButtons
A user with 131 edits. Account created on 15 October 2020.
16 December 2020
- 18:5518:55, 16 December 2020 diff hist +101 User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 18:5318:53, 16 December 2020 diff hist +28 Topoisomerase inhibitor Formating Tag: Visual edit
- 18:5018:50, 16 December 2020 diff hist −7,498 Topoisomerase inhibitor Cut old TopII poisons and TopII inhibitors sections Tag: Visual edit
- 18:4718:47, 16 December 2020 diff hist −689 Topoisomerase inhibitor Cut "Topoisomerase II inhibitors: etoposide (VP-16), teniposide, doxorubicin, daunorubicin, mitoxantrone, amsacrine, ellipticines, aurintricarboxylic acid, and HU-331, a quinone synthesized from cannabidiol." Tag: Visual edit
- 18:4518:45, 16 December 2020 diff hist −8,480 Topoisomerase inhibitor Took out uncited clinical trial information Tag: Visual edit
- 18:3418:34, 16 December 2020 diff hist +41,788 Topoisomerase inhibitor Added antibiotics and anticancer tharaputics sections under Top II inhibitors Tags: nowiki added Visual edit
- 18:3118:31, 16 December 2020 diff hist +4,815 Topoisomerase inhibitor cut "These inhibitors are split into two main classes: topoisomerase poisons, which target the topoisomerase-DNA complex, and topoisomerase inhibitors, which disrupt catalytic turnover. [citation needed)" and added Top II mechanism Tag: Visual edit
- 18:2518:25, 16 December 2020 diff hist −175 Topoisomerase inhibitor reformating Tag: Visual edit
- 18:2318:23, 16 December 2020 diff hist +4,554 Topoisomerase inhibitor added history of noncamptothecin sections, incourperated "Based on these highly favorable characteristics, two indenoisoquinoline derivatives (from a series of > 400 molecules), indotecan (LMP400; NSC 743400) and indimitecan (LMP776; NSC 725776) are presently under evaluation in a Phase I clinical trial being conducted at the National Cancer Institute for patients with relapsed solid tumors and lymphomas." into non-camptothecin section Tag: Visual edit
- 18:2018:20, 16 December 2020 diff hist +515 Topoisomerase inhibitor added to non-campto section, cut repeat, uncited info and info pertaining to nonexistant figures Tag: Visual edit
- 18:1218:12, 16 December 2020 diff hist +1,207 Topoisomerase inhibitor Cut "To circumvent these limitations, Dr. Mark Cushman at Purdue University and Dr. Yves Pommier at the National Cancer Institute developed the non-camptothecin family of indenoisoquinoline inhibitors of Top1. In contrast to the camptothecins, the indenoisoquinolines are: 1) chemically stable in blood, 2) inhibitors of Top1 cleavable complexes at distinct sites, 3) not substrates of membrane transporters, and 4) more effective as anti-tumor agents in animal models." added section that coversthis Tag: Visual edit
- 18:1018:10, 16 December 2020 diff hist +811 Topoisomerase inhibitor Removed "There are, however, certain clinical limitations of the camptothecin derivatives. These include: 1) spontaneous inactivation to a lactone form in blood, 2) rapid reversal of the trapped cleavable complex after drug removal, requiring prolonged infusions, 3) resistance of cancer cells overexpressing membrane transporters, and 4) dose-limiting side effects of diarrhea and neutropenia. [citation needed]" similar info shared in beginning of noncamptothecin section added Tag: Visual edit
- 18:0518:05, 16 December 2020 diff hist −448 Topoisomerase inhibitor Cut "Top1 is a validated target for the treatment of human cancers. Camptothecins are among the most effective anticancer agents recently introduced into clinical practice. In this regard, the camptothecin derivative topotecan (Hycamtin) is approved by the U.S. FDA for the treatment of ovarian and lung cancer. Another camptothecin derivative irinotecan (CPT11) is approved for the treatment of colon cancer. [citation needed]" Similar info covered in "Camptothecin" paragraph II Tag: Visual edit
- 18:0218:02, 16 December 2020 diff hist +8,528 Topoisomerase inhibitor Added "Camptothecins" section to conserve sources Tag: Visual edit
- 17:5817:58, 16 December 2020 diff hist −399 Topoisomerase inhibitor Removed "The Top1-DNA intermediates, known as cleavage complexes, are transient and at low levels under normal circumstances. However, treatment with Top1 inhibitors, such as the camptothecins, stabilize the cleavable complexes, prevent DNA religation and induce lethal DNA strand breaks. Cancer cells are selectively sensitive to the generation of these DNA lesions. [citation needed]" parts encourperated into 2nd half of Top I mechanism Tag: Visual edit
- 17:5717:57, 16 December 2020 diff hist −320 Topoisomerase inhibitor Removal of "Human DNA topoisomerase I (Top1) is an essential enzyme that relaxes DNA supercoiling during replication and transcription. Top1 generates DNA single-strand breaks that allow rotation of the cleaved strand around the double helix axis. Top1 also re-ligates the cleaved strand to reestablish intact duplex DNA." Used in beginning of Top I mechanism Tag: Visual edit
- 17:4917:49, 16 December 2020 diff hist −222 m Topoisomerase inhibitor citation fix Tag: Visual edit
- 17:4817:48, 16 December 2020 diff hist +2,468 Topoisomerase inhibitor Removed: "Topoisomerase I inhibitors: irinotecan, topotecan, camptothecin, diflomotecan and lamellarin D all target type IB topoisomerases," replacing "Classification" with in-depth sections added Topoisomerase I Mechanism Tag: Visual edit
- 17:4317:43, 16 December 2020 diff hist −3,144 Topoisomerase inhibitor Fixed History citations Tag: Visual edit
- 17:4117:41, 16 December 2020 diff hist +4,380 Topoisomerase inhibitor added "After their initial discoveries..." to history Tag: Visual edit
- 17:4017:40, 16 December 2020 diff hist +3,426 Topoisomerase inhibitor added "Topoisomerase inhibitors have been used as..." to history Tag: Visual edit
- 17:3917:39, 16 December 2020 diff hist +2,617 Topoisomerase inhibitor Added "Knowledge of the first..." to history Tag: Visual edit
- 17:3817:38, 16 December 2020 diff hist +351 Topoisomerase inhibitor Added "In the 1940's... epipodophyllotoxin classes." removed "Topoisomerase inhibitors can also function as antibacterial agents. Quinolones (including nalidixic acid and ciprofloxacin) have this function. Quinolones bind to these enzymes and prevent them from decatenation replicating DNA." Tag: Visual edit
- 17:3217:32, 16 December 2020 diff hist +690 Topoisomerase inhibitor insertion of last part of intro, replacement of old intro that stated: "In recent years, topoisomerases have become popular targets for cancer chemotherapy treatments. It is thought that topoisomerase inhibitors block the ligation step of the cell cycle, generating single and double stranded breaks that harm the integrity of the genome. Introduction of these breaks subsequently leads to apoptosis and cell death." Tag: Visual edit
- 17:2817:28, 16 December 2020 diff hist +796 Topoisomerase inhibitor Middle of intro insertion Tag: Visual edit
- 17:2417:24, 16 December 2020 diff hist +629 Topoisomerase inhibitor Start of Edits for Biochem Class Fall 2020: replaced first sentences of intro User:GrumpyButtons/Topoisomerase inhibitor Tag: Visual edit
- 17:1617:16, 16 December 2020 diff hist +98 m User:GrumpyButtons/sandbox No edit summary current Tag: Visual edit
- 17:1417:14, 16 December 2020 diff hist −594 m User:GrumpyButtons/Topoisomerase inhibitor citations Tag: Visual edit
- 17:0517:05, 16 December 2020 diff hist −403 m User:GrumpyButtons/Topoisomerase inhibitor citations Tag: Visual edit
- 17:0217:02, 16 December 2020 diff hist −827 m User:GrumpyButtons/Topoisomerase inhibitor citation changes Tag: Visual edit
- 16:5516:55, 16 December 2020 diff hist −542 m User:GrumpyButtons/Topoisomerase inhibitor source changes Tag: Visual edit
- 14:2614:26, 16 December 2020 diff hist −52 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 09:1609:16, 16 December 2020 diff hist +1 m User:GrumpyButtons/Topoisomerase inhibitor spelling correction Tag: Visual edit
- 07:4507:45, 16 December 2020 diff hist +2 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 07:2207:22, 16 December 2020 diff hist +102 m User:GrumpyButtons/Topoisomerase inhibitor More edits to quinolone section Tag: Visual edit
- 06:5606:56, 16 December 2020 diff hist −2,496 User:GrumpyButtons/Topoisomerase inhibitor Editing my sections Tag: Visual edit
- 02:2802:28, 16 December 2020 diff hist +820 m User:GrumpyButtons/Topoisomerase inhibitor quinolone edits Tag: Visual edit
- 01:5501:55, 16 December 2020 diff hist +24 m User:GrumpyButtons/sandbox No edit summary Tag: Visual edit
- 01:4901:49, 16 December 2020 diff hist +196 User:GrumpyButtons/sandbox Edited quinolone section Tag: Visual edit
- 00:2200:22, 16 December 2020 diff hist +21,254 m User:GrumpyButtons/sandbox No edit summary Tag: Visual edit
- 00:1000:10, 16 December 2020 diff hist +666 m User:GrumpyButtons/sandbox No edit summary Tag: Visual edit
15 December 2020
- 20:3920:39, 15 December 2020 diff hist +276 m User:GrumpyButtons/Topoisomerase inhibitor Anthracycline edits Tag: Visual edit
- 18:1218:12, 15 December 2020 diff hist +213 m User:GrumpyButtons/Topoisomerase inhibitor Edited Doxorubicin and History Tag: Visual edit
- 17:3117:31, 15 December 2020 diff hist −559 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 16:5816:58, 15 December 2020 diff hist +238 m User:GrumpyButtons/Topoisomerase inhibitor added a sentence to possibly insert Tag: Visual edit
- 15:2915:29, 15 December 2020 diff hist +14 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 08:4908:49, 15 December 2020 diff hist +920 User:GrumpyButtons/Topoisomerase inhibitor Edited quinolone section Tag: Visual edit
- 07:2107:21, 15 December 2020 diff hist −416 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 07:0907:09, 15 December 2020 diff hist 0 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
- 06:5206:52, 15 December 2020 diff hist −558 m User:GrumpyButtons/Topoisomerase inhibitor No edit summary Tag: Visual edit
