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Poly(a) binding protein interacting protein 2b

From Wikipedia, the free encyclopedia
PAIP2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPAIP2B, poly(A) binding protein interacting protein 2B
External IDsOMIM: 611018; MGI: 2386865; HomoloGene: 25798; GeneCards: PAIP2B; OMA:PAIP2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020459

NM_146169

RefSeq (protein)

NP_065192

NP_666281

Location (UCSC)Chr 2: 71.18 – 71.23 MbChr 6: 83.78 – 83.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Poly(A) binding protein interacting protein 2B is a protein that in humans is encoded by the PAIP2B gene. [5]

Function

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Most mRNAs, except for histones, contain a 3-prime poly(A) tail. Poly(A)-binding protein (PABP; see MIM 604679) enhances translation by circularizing mRNA through its interaction with the translation initiation factor EIF4G1 (MIM 600495) and the poly(A) tail. Various PABP-binding proteins regulate PABP activity, including PAIP1 (MIM 605184), a translational stimulator, and PAIP2A (MIM 605604) and PAIP2B, translational inhibitors (Derry et al., 2006 [PubMed 17381337]).[supplied by OMIM, Mar 2008].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124374Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045896Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Poly(A) binding protein interacting protein 2B". Retrieved 2018-05-10.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.