LRRC26

LRRC26
Identifiers
Aliases	LRRC26, CAPC, bA350O14.10, leucine rich repeat containing 26
External IDs	OMIM: 613505 MGI: 2385129 HomoloGene: 16228 GeneCards: LRRC26
Gene location (Human) Chr. Chromosome 9 (human) Band 9q34.3 Start 137,168,758 bp End 137,170,051 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 A3 Start 25,179,927 bp End 25,181,192 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in salivary gland minor salivary glands prostate right uterine tube duodenum skin of abdomen thymus body of stomach fundus monocyte Top expressed in ileum duodenum colon jejunum foregut stomach lung urinary bladder olfactory bulb salivary gland More reference expression data BioGPS n/a
Gene ontology Molecular function potassium channel regulator activity protein binding voltage-gated potassium channel activity transmembrane transporter binding potassium channel activator activity Cellular component cytoplasm integral component of membrane voltage-gated potassium channel complex extracellular exosome cytoskeleton membrane fibrillar center nucleolus plasma membrane integral component of plasma membrane Biological process ion transport potassium ion transmembrane transport positive regulation of voltage-gated potassium channel activity transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 389816 227618 Ensembl ENSG00000184709 ENSMUSG00000026961 UniProt Q2I0M4 Q91W20 RefSeq (mRNA) NM_001013653 NM_146117 RefSeq (protein) NP_001013675 NP_666229 Location (UCSC) Chr 9: 137.17 – 137.17 Mb Chr 2: 25.18 – 25.18 Mb PubMed search
Wikidata
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Leucine rich repeat containing 26 (LRRC26) is a protein that in humans is encoded by the LRRC26 gene.

Further reading

• Anaganti S, Hansen JK, Ha D, Hahn Y, Chertov O, Pastan I, Bera TK (March 2009). "Non-AUG translational initiation of a short CAPC transcript generating protein isoform". Biochem. Biophys. Res. Commun. 380 (3): 508–13. doi:10.1016/j.bbrc.2009.01.089. PMC 2664252. PMID 19250639.
• Yan J, Aldrich RW (July 2010). "LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium". Nature. 466 (7305): 513–6. Bibcode:2010Natur.466..513Y. doi:10.1038/nature09162. PMID 20613726. S2CID 4401651.
• Liu XF, Xiang L, Zhang Y, Becker KG, Bera TK, Pastan I (March 2012). "CAPC negatively regulates NF-κB activation and suppresses tumor growth and metastasis". Oncogene. 31 (13): 1673–82. doi:10.1038/onc.2011.355. PMC 3213307. PMID 21822313.
• Gonzalez-Perez V, Xia XM, Lingle CJ (April 2014). "Functional regulation of BK potassium channels by γ1 auxiliary subunits". Proc. Natl. Acad. Sci. U.S.A. 111 (13): 4868–73. Bibcode:2014PNAS..111.4868G. doi:10.1073/pnas.1322123111. PMC 3977294. PMID 24639523.