File:Reaction mechanism for human α-GAL.png
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Summary
| Description |
English: The ligand (black) when bound in the active site of the enzyme (blue). The two key amino acid residues in the active site are Asp-170 and Asp-231. First, Asp-170 performs a nucleophilic attack on the glycosidic bond to release the terminal α-galactose molecule from the ligand. Then, Asp-231 serves as an acid to remove a proton from water, making it more nucleophilic to attack the galactose-Asp complex and release α-galactose from the active site. |
| Date | |
| Source | http://www.jbc.org/content/285/6/3625/F1.expansion.html |
| Author | Abigail I. Guce, Nathaniel E. Clark, Eric N. Salgado, Dina R. Ivanen, Anna A. Kulminskaya, Harry Brumer III‖ and Scott C. Garman |
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 00:59, 10 March 2019 |  | 6,437 × 1,861 (598 KB) | Uahc1 | User created page with UploadWizard |
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