File:ATM target proteins (new).png
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Summary
| Description |
English: ATM-mediated two-step response to DNA double strand breaks. In the rapid response activated ATM phosphorylates effector kinase CHK2 which phosphorylates CDC25A, targeting it for ubiquitination and degradation. Therefore phosphorylated CDK2-Cyclin accumulates and progression through the cell cycle is blocked. In the delayed response ATM phosphorylates the inhibitor of p53, MDM2, and p53 which is also phosphorylated by Chk2. The resulting activation and stabilization of p53 leads to an increased expression of Cdk inhibitor p21, which further helps to keep Cdk activity low and to maintain long-term cell cycle arrest. |
| Date | (UTC) |
| Source | Own work (Original text: I (Cellular Biochemistry II (talk)) created this work entirely by myself.) |
| Author | Cellular Biochemistry II (talk) |
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Original upload log
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| Date/Time | Dimensions | User | Comment |
|---|---|---|---|
| 2010-06-21 20:54 | 2961×2346× (93304 bytes) | Cellular Biochemistry II | {{Information |Description = |Source = I (~~~) created this work entirely by myself. |Date = ~~~~~ |Author = ~~~ |other_versions = }} |
| 2010-06-21 19:15 | 2955×2339× (92620 bytes) | Cellular Biochemistry II | {{Information |Description = |Source = I (~~~) created this work entirely by myself. |Date = ~~~~~ |Author = ~~~ |other_versions = }} |
| 2010-06-21 19:14 | 3940×3118× (135063 bytes) | Cellular Biochemistry II | {{Information |Description = |Source = I (~~~) created this work entirely by myself. |Date = ~~~~~ |Author = ~~~ |other_versions = }} |
| 2010-06-21 19:14 | 4925×3897× (181778 bytes) | Cellular Biochemistry II | {{Information |Description = |Source = I (~~~) created this work entirely by myself. |Date = ~~~~~ |Author = ~~~ |other_versions = }} |
| 2010-06-21 19:13 | 9850×7794× (75632 bytes) | Cellular Biochemistry II | {{Information |Description = |Source = I (~~~) created this work entirely by myself. |Date = ~~~~~ |Author = ~~~ |other_versions = }} |
| 2010-06-21 19:11 | 11857×9386× (109231 bytes) | Cellular Biochemistry II | {{Information |Description = |Source = I (~~~) created this work entirely by myself. |Date = ~~~~~ |Author = ~~~ |other_versions = }} |
File history
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 20:04, 1 October 2016 |  | 2,961 × 2,346 (43 KB) | Cmdrjameson | Compressed with pngout. Reduced by 48kB (53% decrease). |
| 04:53, 26 August 2015 |  | 2,961 × 2,346 (91 KB) | OgreBot | (BOT): Reverting to most recent version before archival | |
| 04:53, 26 August 2015 |  | 2,955 × 2,339 (90 KB) | OgreBot | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:15:59 by Cellular Biochemistry II | |
| 04:53, 26 August 2015 |  | 3,940 × 3,118 (132 KB) | OgreBot | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:14:59 by Cellular Biochemistry II | |
| 04:53, 26 August 2015 |  | 4,925 × 3,897 (178 KB) | OgreBot | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:14:13 by Cellular Biochemistry II | |
| 04:53, 26 August 2015 |  | 9,850 × 7,794 (74 KB) | OgreBot | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:13:12 by Cellular Biochemistry II | |
| 04:53, 26 August 2015 |  | 11,857 × 9,386 (107 KB) | OgreBot | (BOT): Uploading old version of file from en.wikipedia; originally uploaded on 2010-06-21 19:11:50 by Cellular Biochemistry II | |
| 04:50, 26 August 2015 |  | 2,961 × 2,346 (91 KB) | NickW557 | Transferred from en.wikipedia |
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