Aspartylglucosaminidase

From Wikipedia, the free encyclopedia
AGA
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGA, Aga, AW060726, AGU, ASRG, GA, aspartylglucosaminidase
External IDsOMIM: 613228 MGI: 104873 HomoloGene: 13 GeneCards: AGA
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000027
NM_001171988

NM_001005847
NM_001205054

RefSeq (protein)

NP_000018
NP_001165459

NP_001005847
NP_001191983

Location (UCSC)Chr 4: 177.43 – 177.44 MbChr 8: 53.96 – 53.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase is an enzyme that in humans is encoded by the AGA gene.[5]

Aspartylglucosaminidase is an amidohydrolase enzyme involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000038002 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031521 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: AGA aspartylglucosaminidase".

External links[edit]

Further reading[edit]

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