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Andreas Horn

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Andreas Horn
Born
Freiburg, Germany
Alma materUniversity of Freiburg
Known forDeep Brain Stimulation, functional neuroimaging
AwardsGerman Research Foundation Heinz Maier-Leibnitz-Preis, Clarivate Highly Cited Researchers
Scientific career
FieldsNeuroimaging neurology
InstitutionsHarvard Medical School, Brigham & Women's Hospital, Massachusetts General Hospital

Andreas Horn is a German neuroscientist and Associate Professor of Neurology at Harvard Medical School and Mass General Brigham. His research has focused on mapping deep brain stimulation outcomes onto networks of the human brain. Horn's work has been featured by media outlets such as CNN[1], Newsweek[2] or Fox News[3] and he has been considered among the 'World's Highly Cited Researchers' by Clarivate[4].

Education and early career

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Horn studied medicine at University of Freiburg and received his MD in 2012. He then pursued a PhD in Medical Neurosciences at Charité Berlin which he completed in 2016. After working in several postdoctoral roles, he was enrolled into the Emmy Noether Program by the German Research Foundation and started a laboratory at Charité in 2018. In 2022, he became Associate Professor of Neurology at Harvard Medical School and affiliated with Brigham and Women's and Massachusetts General Hospital.

Research contributions

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Horn is known for his work in brain circuit mapping and neuromodulation. He developed methods to localize deep brain stimulation electrodes and to estimate networks stimulated by them. His research has also explored how brain stimulation sites and lesions correlate with specific brain circuits, providing insights into various neurological and psychiatric conditions such as Parkinson’s disease[5], obsessive-compulsive-disorder[6], Alzheimer's Disease[7], and dystonia[8]. He and his team developed methods such as Lead-DBS and subcortical electrophysiology mapping and DBS network mapping[9].

Selected honors and awards

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Selected publications

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  • Hollunder B, Ostrem JL, Sahin IA, Rajamani N, Oxenford S, Butenko K, Neudorfer C, Reinhardt P, Zvarova P, Polosan M, Akram H, Vissani M, Zhang C, Sun B, Navratil P, Reich MM, Volkmann J, Yeh FC, Baldermann JC, Dembek TA, Visser-Vandewalle V, Alho EJL, Franceschini PR, Nanda P, Finke C, Kühn AA, Dougherty DD, Richardson RM, Bergman H, DeLong MR, Mazzoni A, Romito LM, Tyagi H, Zrinzo L, Joyce EM, Chabardes S, Starr PA, Li N, Horn A. Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation. Nat Neurosci. 2024;27(3):573-586.[15]
  • Ríos AS, Oxenford S, Neudorfer C, Butenko K, Li N, Rajamani N, Boutet A, Elias GJB, Germann J, Loh A, Deeb W, Wang F, Setsompop K, Salvato B, Almeida LB de, Foote KD, Amaral R, Rosenberg PB, Tang-Wai DF, Wolk DA, Burke AD, Salloway S, Sabbagh MN, Chakravarty MM, Smith GS, Lyketsos CG, Okun MS, Anderson WS, Mari Z, Ponce FA, Lozano AM, Horn A. Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer’s disease. Nat Commun. 2022;13(1):7707.[7]
  • Rajamani N, Friedrich H, Butenko K, Dembek T, Lange F, Navrátil P, Zvarova P, Hollunder B, De Bie RMA, Odekerken VJJ, Volkmann J, Xu X, Ling Z, Yao C, Ritter P, Neumann WJ, Skandalakis GP, Komaitis S, Kalyvas A, Koutsarnakis C, Stranjalis G, Barbe M, Milanese V, Fox MD, Kühn AA, Middlebrooks E, Li N, Reich M, Neudorfer C, Horn A. Deep brain stimulation of symptom-specific networks in Parkinson’s disease. Nat Commun. 2024;15(1):4662.[16]
  • Horn A, Reich M, Vorwerk J, Li N, Wenzel G, Fang Q, Schmitz-Hübsch T, Nickl R, Kupsch A, Volkmann J, Kühn AA, Fox MD. Connectivity Predicts deep brain stimulation outcome in Parkinson disease: DBS Outcome in PD. Ann Neurol. 2017;82(1):67-78.[17]

References

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  1. ^ Goodman, Brenda (2024-03-15). "Deep brain stimulation didn't work for a young OCD patient until new brain maps changed everything". CNN. Retrieved 2024-11-19.
  2. ^ Reporter, Pandora Dewan Senior Science (2024-02-26). "Neuroscientists say new brain map could help tackle disorders". Newsweek. Retrieved 2024-11-19.
  3. ^ Rudy, Melissa (2024-03-04). "Researchers find sources of four brain disorders, which could lead to new treatments". Fox News. Retrieved 2024-11-19.
  4. ^ a b "Highly Cited Researchers | Clarivate". clarivate.com. 2024-11-13. Retrieved 2024-11-19.
  5. ^ Sobesky, Leon; Goede, Lukas; Odekerken, Vincent J J; Wang, Qiang; Li, Ningfei; Neudorfer, Clemens; Rajamani, Nanditha; Al-Fatly, Bassam; Reich, Martin; Volkmann, Jens; de Bie, Rob M A; Kühn, Andrea A; Horn, Andreas (2022-03-29). "Subthalamic and pallidal deep brain stimulation: are we modulating the same network?". Brain. 145 (1): 251–262. doi:10.1093/brain/awab258. ISSN 0006-8950. PMID 34453827.
  6. ^ Li, Ningfei; Baldermann, Juan Carlos; Kibleur, Astrid; Treu, Svenja; Akram, Harith; Elias, Gavin J. B.; Boutet, Alexandre; Lozano, Andres M.; Al-Fatly, Bassam; Strange, Bryan; Barcia, Juan A.; Zrinzo, Ludvic; Joyce, Eileen; Chabardes, Stephan; Visser-Vandewalle, Veerle (2020-07-03). "A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder". Nature Communications. 11 (1): 3364. doi:10.1038/s41467-020-16734-3. ISSN 2041-1723. PMC 7335093. PMID 32620886.
  7. ^ a b Ríos, Ana Sofía; Oxenford, Simón; Neudorfer, Clemens; Butenko, Konstantin; Li, Ningfei; Rajamani, Nanditha; Boutet, Alexandre; Elias, Gavin J. B.; Germann, Jurgen; Loh, Aaron; Deeb, Wissam; Wang, Fuyixue; Setsompop, Kawin; Salvato, Bryan; Almeida, Leonardo Brito de (2022-12-14). "Optimal deep brain stimulation sites and networks for stimulation of the fornix in Alzheimer's disease". Nature Communications. 13 (1): 7707. doi:10.1038/s41467-022-34510-3. ISSN 2041-1723. PMC 9751139. PMID 36517479.
  8. ^ Horn, Andreas; Reich, Martin M.; Ewert, Siobhan; Li, Ningfei; Al-Fatly, Bassam; Lange, Florian; Roothans, Jonas; Oxenford, Simon; Horn, Isabel; Paschen, Steffen; Runge, Joachim; Wodarg, Fritz; Witt, Karsten; Nickl, Robert C.; Wittstock, Matthias (2022-04-05). "Optimal deep brain stimulation sites and networks for cervical vs. generalized dystonia". Proceedings of the National Academy of Sciences. 119 (14): e2114985119. doi:10.1073/pnas.2114985119. ISSN 0027-8424. PMC 9168456. PMID 35357970.
  9. ^ Horn, Andreas; Reich, Martin; Vorwerk, Johannes; Li, Ningfei; Wenzel, Gregor; Fang, Qianqian; Schmitz-Hübsch, Tanja; Nickl, Robert; Kupsch, Andreas; Volkmann, Jens; Kühn, Andrea A.; Fox, Michael D. (July 2017). "Connectivity Predicts deep brain stimulation outcome in P arkinson disease". Annals of Neurology. 82 (1): 67–78. doi:10.1002/ana.24974. ISSN 0364-5134. PMC 5880678. PMID 28586141.
  10. ^ Ioannidis, John P. A. (2024-09-16). "August 2024 data-update for "Updated science-wide author databases of standardized citation indicators"". elsevier.digitalcommonsdata.com. 7. doi:10.17632/btchxktzyw.7.
  11. ^ "Dr. Andreas Horn - Heinz Maier-Leibnitz-Preisträger 2022". www.dfg.de (in German). Retrieved 2024-11-19.
  12. ^ "International Brain Stimulation Conference | Participate | Elsevier". www.elsevier.com. Retrieved 2024-09-17.
  13. ^ "International Brain Stimulation Conference | Participate | Elsevier". www.elsevier.com. Retrieved 2024-11-19.
  14. ^ "Mapping the Human Dysfunctome: Andreas Horn's Innovative Approach to Brain Disorders | Falling Walls". falling-walls.com. Retrieved 2024-11-19.
  15. ^ Hollunder, Barbara; Ostrem, Jill L.; Sahin, Ilkem Aysu; Rajamani, Nanditha; Oxenford, Simón; Butenko, Konstantin; Neudorfer, Clemens; Reinhardt, Pablo; Zvarova, Patricia; Polosan, Mircea; Akram, Harith; Vissani, Matteo; Zhang, Chencheng; Sun, Bomin; Navratil, Pavel (March 2024). "Mapping dysfunctional circuits in the frontal cortex using deep brain stimulation". Nature Neuroscience. 27 (3): 573–586. doi:10.1038/s41593-024-01570-1. ISSN 1097-6256. PMC 10917675. PMID 38388734.
  16. ^ Rajamani, Nanditha; Friedrich, Helen; Butenko, Konstantin; Dembek, Till; Lange, Florian; Navrátil, Pavel; Zvarova, Patricia; Hollunder, Barbara; de Bie, Rob M. A.; Odekerken, Vincent J. J.; Volkmann, Jens; Xu, Xin; Ling, Zhipei; Yao, Chen; Ritter, Petra (2024-05-31). "Deep brain stimulation of symptom-specific networks in Parkinson's disease". Nature Communications. 15 (1): 4662. doi:10.1038/s41467-024-48731-1. ISSN 2041-1723. PMC 11143329. PMID 38821913.
  17. ^ Horn, Andreas; Reich, Martin; Vorwerk, Johannes; Li, Ningfei; Wenzel, Gregor; Fang, Qianqian; Schmitz-Hübsch, Tanja; Nickl, Robert; Kupsch, Andreas; Volkmann, Jens; Kühn, Andrea A.; Fox, Michael D. (July 2017). "Connectivity Predicts deep brain stimulation outcome in P arkinson disease". Annals of Neurology. 82 (1): 67–78. doi:10.1002/ana.24974. ISSN 0364-5134. PMC 5880678. PMID 28586141.

See also

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