ACER1

ACER1
Identifiers
Aliases	ACER1, ALKCDase1, ASAH3, alkaline ceramidase 1
External IDs	OMIM: 613491 MGI: 2181962 HomoloGene: 15853 GeneCards: ACER1
Gene location (Human)
Chr.	Chromosome 19 (human)
End	6,333,612 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	57,289,126 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; vulva; ; human penis; ; nipple; ; oral cavity; ; vagina; ; lymph node; ; blood; ; thymus; ; right lobe of liver;
	Top expressed in
	lip; ; condyle; ; skin of back; ; epithelium of stomach; ; left colon; ; epidermis; ; skin of abdomen; ; Paneth cell; ; hair follicle; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	dihydroceramidase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; hydrolase activity; N-acylsphingosine amidohydrolase activity; ceramidase activity; metal ion binding;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum;
Biological process	cellular response to calcium ion; regulation of lipid metabolic process; cell differentiation; sphingosine biosynthetic process; sphingolipid biosynthetic process; response to alkaline pH; keratinocyte differentiation; ceramide metabolic process; epidermis development; lipid metabolism; ceramide catabolic process; sphingolipid metabolic process; regulation of water loss via skin; sebaceous gland development;
	Sources:Amigo / QuickGO
Orthologs
	125981
	171168
	ENSG00000167769
	ENSMUSG00000045019
	Q8TDN7
	Q8R4X1
	NM_133492
	NM_175731
	NP_597999
	NP_783858
	Wikidata
View/Edit Human	View/Edit Mouse

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.^[5]

Function[edit]

ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).^[5]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167769 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045019 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM (Aug 2003). "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides". The Journal of Biological Chemistry. 278 (33): 31184–91. doi:10.1074/jbc.M303875200. PMID 12783875.

External links[edit]

Human ACER1 genome location and ACER1 gene details page in the UCSC Genome Browser.

Further reading[edit]

Sun W, Xu R, Hu W, Jin J, Crellin HA, Bielawski J, Szulc ZM, Thiers BH, Obeid LM, Mao C (Feb 2008). "Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes". The Journal of Investigative Dermatology. 128 (2): 389–97. doi:10.1038/sj.jid.5701025. PMID 17713573.
Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D, de Daruvar A, Wincker P, Serre G, Guerrin M (2007). "Large-scale identification of human genes implicated in epidermal barrier function". Genome Biology. 8 (6): R107. doi:10.1186/gb-2007-8-6-r107. PMC 2394760. PMID 17562024.
Ito M, Okino N, Tani M, Mitsutake S, Mori K (Mar 2002). "[Molecular evolution of neutral ceramidase: signalling molecule and virulence factor]". Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme. 47 (4 Suppl): 455–62. PMID 11915342.
Houben E, Holleran WM, Yaginuma T, Mao C, Obeid LM, Rogiers V, Takagi Y, Elias PM, Uchida Y (May 2006). "Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis". Journal of Lipid Research. 47 (5): 1063–70. doi:10.1194/jlr.M600001-JLR200. PMID 16477081.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167769 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045019 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12783875-5] Mao C, Xu R, Szulc ZM, Bielawski J, Becker KP, Bielawska A, Galadari SH, Hu W, Obeid LM (Aug 2003). "Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides". The Journal of Biological Chemistry. 278 (33): 31184–91. doi:10.1074/jbc.M303875200. PMID 12783875.

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