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4-Methylaminobutanoate oxidase (methylamine-forming)

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4-methylaminobutanoate oxidase (methylamine-forming)
Identifiers
EC no.1.5.3.21
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
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MetaCycmetabolic pathway
PRIAMprofile
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NCBIproteins

4-methylaminobutanoate oxidase (methylamine-forming) (EC 1.5.3.21, mao (gene)) is an enzyme with systematic name 4-methylaminobutanoate methylamidohydrolase.[1][2] This enzyme catalyses the following chemical reaction

4-methylaminobutanoate + O2 + H2O succinate semialdehyde + methylamine + H2O2

The enzyme participates in the nicotine degradation in soil bacterium Arthrobacter nicotinovorans.

References

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  1. ^ Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R (December 2004). "A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1" (PDF). European Journal of Biochemistry. 271 (23–24): 4677–84. doi:10.1111/j.1432-1033.2004.04432.x. PMID 15606755.
  2. ^ Chiribau CB, Mihasan M, Ganas P, Igloi GL, Artenie V, Brandsch R (April 2006). "Final steps in the catabolism of nicotine". The FEBS Journal. 273 (7): 1528–36. doi:10.1111/j.1742-4658.2006.05173.x. PMID 16689938.
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